Utility and Usability of ActivSight™ Laser Speckle Imaging in Visualization of Tissue Perfusion and Blood Flow During Esophageal Surgery in Humans

INCLUSION CRITERIA All patients age \> 18 years old undergoing laparoscopic esophageal resection and reconstruction surgery; spoken command and literacy in the native language spoken at each participating center; ability to understand and follow study procedures; and having provided signed consent. Diagnosis: * All patients with a clinical suspicion and diagnosis of benign or malignant, small or large bowel lesions requiring surgical resection. * Typical imaging as per standard workup findings including US, CT and/or MRI. Plain radiographs and contrast imaging may be obtained by referring physicians and are helpful for confirming the clinical diagnosis. Location of pathology or resected segment: \* Target lesions can be located in any fore-, mid- or hindgut segments requiring reconstruction and anastomoses. Prior therapy: \* Patients with prior surgery are eligible for enrollment. Laboratory: * Hemoglobin \> 9 g/dL * Platelet count ≥75,000/µL (may receive transfusions) * Normal PT, PTT and INR \< 1.5 x ULN (including patients on prophylactic anticoagulation) * Renal function: Age-adjusted normal serum creatinine derived from Schwartz formula for estimating GFR by the CDC OR a creatinine clearance ≥60 mL/min/1.73 m2 for safe * Adequate pulmonary function: Defined as no dyspnea at rest, and a pulse oximetry \>94% on room air if there is clinical indication for determination. EXCLUSION CRITERIA * There is no exclusion criteria for ActivSightTM for esophageal surgery. …