CompletedPhase 1

Effects of Anesthetic Infusion on the Amplitude of Motor Evoked Potential in Pediatrics Undergoing Tethered Spinal Cord Surgeries

Egypt46 participantsStarted 2022-10-30

Plain-language summary

The tethered spinal cord is a common pathology in pediatric neurosurgery. Intraoperative neurophysiologic monitoring (IOM) has gained popularity over the past two decades as a clinical discipline that uses neurophysiologic techniques to detect and prevent iatrogenic neurologic injuries. IOM techniques are extensively used in adult neurosurgery and, in their principles, can be applied to the pediatric population. Inhalational agents cause a dose-dependent reduction in MEPs and are arguably considered incompatible with effective neurophysiological monitoring(5) For this reason, total intravenous anesthesia (TIVA), using IV anesthetics (propofol or ketamine) and opioids (fentanyl or remifentanil), is commonly used in spinal surgeries under MEPs monitoring

Who can participate

Age range3 Years – 8 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * children with ASA I and II presented to Abu elreesh hospital for untethered spinal cord surgery. Exclusion Criteria: * Children with neuromuscular diseases or congenital scoliosis. * Children with growing rod distraction surgery. * Children with American Society of Anaesthesiologists (ASA) physical status III, IV * Children with preoperative use of antidepressant or anticonvulsant medications. * Children with a known history of drug allergies.

What they're measuring

the mean microvolts of 3 measurements of MEPs at 5 minutes interval at AH muscle before skin incision.

Timeframe: 2 hours

Trial details

NCT IDNCT05591001

SponsorCairo University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2023-03-20

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