This study is designed to investigate the effects of a beta-adrenergic antagonist (Propranolol; 40 mg IR) and nicotine patch (14 mg) administered alone and in combination on neurobiological and behavioral responses to smoking cues in ongoing cigarette smokers. This is a basic experimental study in humans and participants will not take these medications for an extended period or make a cessation attempt as part of their involvement in this research project.
Age range
21 Years – 60 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Cue-Provoked Craving Ratings
Timeframe: Approximately 4-5 hours
Blood-Oxygen Level Dependent (BOLD) Activation to Smoking Cues
Timeframe: Approximately 4-5 hours
Association between Smoking Urge and Brain Activation
Timeframe: Approximately 4-5 hours
Hippocampus-Amygdala connectivity to smoking cues
Timeframe: Approximately 4-5 hours
Medial Prefrontal Cortex and Posterior Cingulate Cortex connectivity
Timeframe: Approximately 4-5 hours
Association between Smoking Urge and Brain Connectivity
Timeframe: Approximately 4-5 hours