CompletedNot Applicable

Determining the Relationship Between Gut Microbiota and Immune Response to Influenza or COVID-19 Vaccine

United States46 participantsStarted 2023-11-03

Plain-language summary

This study will evaluate the effect of the microorganisms in the gut on how well the flu or COVID-19 vaccine works in people who have a weakened immune system due to inflammatory bowel disease. Participants can expect to be in the study for up to 65 days.

Who can participate

Age range18 Years – 64 Years

SexALL

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Inclusion criteria

✓. Group A: Anti-TNF Therapy Group
✓. Group B: Non-TNG biologic
✓. Group C: Janus Kinase Therapy

What they're measuring

Influenza or COVID-17 antibody concentrations

Timeframe: Baseline

Influenza or COVID-19 antibody concentrations

Timeframe: One blood draw between 28-65 days after baseline

Microbiome metrics

Timeframe: One stool collection between days 0-65

Microbiome stability

Timeframe: One stool collection between days 0-65

Trial details

NCT IDNCT05584735

SponsorUniversity of Wisconsin, Madison

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2025-03-20

View on ClinicalTrials.gov More Inflammatory Bowel Diseases trials