Restoring Neural Oscillatory Communication in Developmental Dyslexia (NCT05583136) | Clinical Trial Compass
CompletedNot Applicable
Restoring Neural Oscillatory Communication in Developmental Dyslexia
Italy78 participantsStarted 2021-12-14
Plain-language summary
Developmental dyslexia (DD) is a multifactorial disorder that hampers the education of about 10% of individuals across cultures and is associated to both phonological and visual deficits. The latter have been linked to a deficit in the magnocellular-dorsal (M-D) visual stream, that has a critical role in guiding the activity of ventral visual stream areas where letters identity is extracted. Here, we will test the efficacy of transcranial alternate current stimulation (tACS) of the M-D stream combined with reading trainings in adult participants with DD, assessing the neurophysiological underpinnings of these new trainings with EEG and fMRI/DTI.
Who can participate
Age range
18 Years – 35 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Adult patient (age between 18 and 35)
* Official Diagnosis of Developmental Dyslexia (DD)
* Normal or corrected-to-normal vision and hearing
* Normal motor skills
Exclusion Criteria:
* Participants that cannot sign the consent form
* Participants unable to read or understand and correctly complete the procedures foreseen by the study
* Participants with a diagnosis or personal history of epilepsy or patients with a positive family history of epilepsy
* Pregnant or breastfeeding patients
* Participants with major psychiatric or neurological disorders and/or currently in psychopharmacological treatments.
* Participants with metal implants in the brain, pacemakers, brain stimulators, cochlear implants.
* Participants with claustrophobia (only for fMRI)
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Reading score
Timeframe: Pre-training, 1-7 days post-training, follow-up at 1 and 6 months