CompletedNot Applicable

Respiratory Muscles After Inspiratory Muscle Training After COVID-19

Germany18 participantsStarted 2022-10-17

Plain-language summary

It is the aim of the current (follow-up) project for the first time in post-COVID-19 patients who continue to complain of shortness of breath and for whom there is no other explanation than possibly proven diaphragmatic weakness, to determine the effects of 6 weeks of IMT/diaphragm training on diaphragm strength and shortness of breath.

Who can participate

Age range18 Years – 80 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * 18 patients with survived COVID-19, persistent otherwise unexplainable dyspnoea and proven diaphragm dysfunction * Patients aged at least 18 years, who are mentally and physically able to consent and participate into the study Exclusion Criteria: * Diagnosis of another disease, which causes a permanent increase in carbon dioxide level in the blood (chronic hypercapnia) or a permanent combined lung weakness (particularly a neuromuscular disease) * Body-mass-index (BMI) \>40 * Expected absence of active participation of the patient in study-related measurements * Alcohol or drug abuse * Metal implant in the body that is not MRI compatible (NON MRI compatible pacemaker, implantable defibrillator, cervical implants, e.g. brain pacemakers etc.) * Slipped disc * Epilepsy

What they're measuring

Twitch transdiaphragmatic pressure in response to supramaximal magnetic stimulation of the phrenic nerve roots (Unit: Pressure in cmH2O)

Timeframe: Assessed at baseline

Twitch transdiaphragmatic pressure in response to supramaximal magnetic stimulation of the phrenic nerve roots (Unit: Pressure in cmH2O)

Timeframe: Assessed after 6 weeks of IMT

Twitch transdiaphragmatic pressure in response to supramaximal magnetic stimulation of the phrenic nerve roots (Unit: Pressure in cmH2O)

Timeframe: Assessed 6 weeks after IMT

Respiratory mouth pressures

Timeframe: Assessed at baseline

Respiratory mouth pressures

Timeframe: Assessed after 6 weeks of IMT

Respiratory mouth pressures

Timeframe: Assessed 6 weeks after IMT

Trial details

NCT IDNCT05582642

SponsorRWTH Aachen University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2024-06-01

View on ClinicalTrials.gov More COVID-19 trials

Plain-language summary

Who can participate

Age range18 Years – 80 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Twitch transdiaphragmatic pressure in response to supramaximal magnetic stimulation of the phrenic nerve roots (Unit: Pressure in cmH2O)

Timeframe: Assessed at baseline

Twitch transdiaphragmatic pressure in response to supramaximal magnetic stimulation of the phrenic nerve roots (Unit: Pressure in cmH2O)

Timeframe: Assessed after 6 weeks of IMT

Twitch transdiaphragmatic pressure in response to supramaximal magnetic stimulation of the phrenic nerve roots (Unit: Pressure in cmH2O)

Timeframe: Assessed 6 weeks after IMT

Respiratory mouth pressures

Timeframe: Assessed at baseline

Respiratory mouth pressures

Timeframe: Assessed after 6 weeks of IMT

Respiratory mouth pressures

Timeframe: Assessed 6 weeks after IMT