CompletedNot Applicable

Regenerative Endodontics Using Different Intracanal Medicaments on Radiographic Outcomes and Periapical MMP-8 Levels

Turkey (Türkiye)23 participantsStarted 2017-09-01

Plain-language summary

Two-session regenerative endodontic treatment was applied to 20 immature mandibular first molars with symptomatic irreversible pulpitis and symptomatic apical periodontitis. At the end of the first session, calcium hydroxide \[Ca(OH)2\] was applied to 10 randomly selected teeth and double antibiotic paste (DAP) intracanal medicaments were applied to the other 10 teeth. The effects of intracanal medicaments on periapical MMP-8 levels were determined by immunofluorometric assay (IFMA) in periapical tissue fluid samples taken from the distal root canal in the first and second sessions.

Who can participate

Age range6 Years – 9 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: \- Healthy children with irreversible pulpitis with symptomatic apical periodontitis (SIP-SAP), indication for RET and informed consent from the patients. Exclusion Criteria: * Children with extra oral swelling or luxation with a deep periodontal pocket and whom application of RET was contraindicated. * The teeth were indicated for vital pulp therapy (assesed during treatment) * Children who have used antibiotics in the past 3 months and are uncooperative during treatment * Children who have used any painkillers during the treatment

What they're measuring

Clinical healing according to presence of clinical symptoms

Timeframe: 12 months

Periapical healing according to change in amount of root hard tissues

Timeframe: 12 months

MMP-8 levels from periapical tissue fluid samples

Timeframe: 14 day

Trial details

NCT IDNCT05581706

SponsorEge University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2020-02-01