CompletedNot Applicable

TB Case-Finding, Treatment and Prevention Intervention in Thailand

Thailand7,455 participantsStarted 2024-05-07

Plain-language summary

The project aimed to test a strategy for the early detection and prevention of tuberculosis in household contacts of tuberculosis patients in order to reduce the morbidity, mortality and transmission of this disease in Thailand. This strategy will be evaluated in comparison with the current programmatic approach through a pragmatic trial with cluster randomization (cluster randomized controlled trial) which will be conducted over the next 3 years. This project is carried out in collaboration with the Tuberculosis Division of the Ministry of Public Health of Thailand, the TB/HIV Research Foundation in Thailand and the London School of Hygiene and Tropical Medicine in England.

Who can participate

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: Inclusion of the index cases * Age ≥18 years * Newly bacteriologically confirmed TB case (within 1 month of diagnosis) * Living in the same household for the last 3 months * Reporting at least one HH contact * Providing written informed consent for participation in the study Inclusion of contacts * All contacts living in the same HH, defined as any person who shared the same enclosed living space as the index TB case for one or more nights or for frequent or extended daytime periods for at least one month before the TB diagnosis is made. * Providing written informed consent (signed by adult (≥18 years) contacts; or by parents/guardians for minors \< 13 years or incapacitated people; written assent for children ≥13 years and \< 18 years). Exclusion Criteria: Exclusion of index cases * Index case who do not live in the catchment area of the study cluster * Index cases diagnosed with rifampicin resistance, multidrug resistance (MDR) or extensively drug-resistant (XDR-TB) * Index cases who are incarcerated Exclusion of the contacts \- contact currently on TPT or on TB treatment or who finished such treatment in the last 3 months.

What they're measuring

Proportion of household contacts with active tuberculosis excluded who are initiated on tuberculosis preventive treatment within 4 weeks of the index tuberculosis patient diagnosis - overall

Timeframe: Month18

Proportion of household contacts with active tuberculosis excluded who are initiated on tuberculosis preventive treatment within 4 weeks of the index tuberculosis patient diagnosis - by age group (<15, ≥15 years)

Timeframe: Month18

Proportion of household contacts with active tuberculosis excluded who are initiated on tuberculosis preventive treatment within 4 weeks of the index tuberculosis patient diagnosis - by gender

Timeframe: Month18

Trial details

NCT IDNCT05581212

SponsorInstitut de Recherche pour le Developpement

Sponsor typeOTHER_GOV

Study typeINTERVENTIONAL

Primary completion2026-01-06

View on ClinicalTrials.gov More Tuberculosis trials

Plain-language summary

Who can participate

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Proportion of household contacts with active tuberculosis excluded who are initiated on tuberculosis preventive treatment within 4 weeks of the index tuberculosis patient diagnosis - overall

Timeframe: Month18

Proportion of household contacts with active tuberculosis excluded who are initiated on tuberculosis preventive treatment within 4 weeks of the index tuberculosis patient diagnosis - by gender

Timeframe: Month18