RecruitingNot Applicable

Thyroid Function and Structure in Klinefelter Syndrome

Italy600 participantsStarted 2007-05-11

Plain-language summary

This is a longitudinal retrospective study for the evaluation of thyroid function and structure in patients with Klinefelter syndrome compared to healthy controls and patients affected by chronic lymphocytic thyroiditis.

Who can participate

Age range1 Year – 80 Years

SexMALE

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Patients with a confirmed diagnosis of classic, non-mosaic 47,XXY Klinefelter syndrome based on a peripheral blood 97 karyotype analysis; * Availability of thyroid function test results (TSH, fT3, and fT4) and/or thyroid US imaging; * Availability of concurrent clinical data. Exclusion Criteria: * Presence of other known genetic conditions or chromosomal abnormalities; * Use of levothyroxine or other drugs that are either active on the hypothalamic-pituitary-thyroid (HPT) axis or that may interfere with thyroid function tests; * History of previous surgery or radiotherapy on the thyroid or pituitary glands; * Current or previous T therapy (for the pre-pubertal and pubertal groups).

What they're measuring

Peripheral blood TSH concentration

Timeframe: Through study completion, an average of 6 years

Peripheral blood fT3 concentration

Timeframe: Through study completion, an average of 6 years

Peripheral blood fT4 concentration

Timeframe: Through study completion, an average of 6 years

Trial details

NCT IDNCT05581147

SponsorUniversity of Roma La Sapienza

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2019-10-15

Contact for this trial

Andrea M Isidori, MD, PhD

0039649970711 andrea.isidori@uniroma1.it

View on ClinicalTrials.gov More Klinefelter Syndrome trials