CompletedNot Applicable

Pressure Gradient vs. Flow Relationships in Patients With Symptomatic Valvular Aortic Stenosis

Denmark26 participantsStarted 2019-09-01

Plain-language summary

The objective of the present study is to investigate to hemodynamic profile at rest and during peak exercise of patients with suspected severe aortic stenosis and to compare flow- and pressure changes between high gradient patients and low gradient patients.

Who can participate

Age range18 Years – 100 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Patients with suspected severe AS scheduled for evaluation for aortic valve intervention: * LVEF \> 50 % * AVA \< 1.0 cm2 * Symptomatic - at least equivalent to NYHA functional class II Exclusion Criteria: * Congenital heart disease * Severe coronary artery disease (main stem, proximal LAD or 3 vessel disease) * Moderate or severe aortic valve regurgitation * Moderate or severe mitral valve regurgitation or stenosis * Moderate or severe pulmonary valve regurgitation or stenosis * Moderate or severe tricuspid valve regurgitation or stenosis * Severe pulmonary hypertension (tricuspid valve pressure gradient of 60 mmHg) * Right ventricular dysfunction (TAPSE \< 17 mm) * Restrictive cardiomyopathy or cardiac amyloidosis * Constrictive pericarditis * Inability to perform supine bicycle exercise

What they're measuring

Pressure and flow relationships across the aortic valve during rest and during supine exercise

Timeframe: 2 hours

Trial details

NCT IDNCT05580237

SponsorAarhus University Hospital Skejby

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2023-12-01

View on ClinicalTrials.gov More Aortic Valve Stenosis trials