Not Yet RecruitingPhase 4

Effect of Prednisone and Aspirin on IVF-ET Outcome Among Patients With Thyroid Autoimmunity

540 participantsStarted 2022-11-01

Plain-language summary

This trial was a 1:1 (active:placebo) randomized, double-blind, placebo-controlled trial to evaluate the safety and efficacy of prednisone and aspirin for the in vitro fertilization and embryo transfer outcome among patients with thyroid autoimmunity.

Who can participate

Age range20 Years – 38 Years

SexFEMALE

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Inclusion criteria

✓. TPOAb\>34IU/ml and/or TgAb\>115IU/ml
✓. ≥5 follicles with average diameter lager than 14 mm at trigger day
✓. ≥5 oocytes retrieved
✓. for frozen embryo transfer, at least 2 cleavage stage embryos, among which at least one morphologically good quality embryo, or at least 1 morphologically good quality embryo in blastocyst stage
✓. age: 20-38 years old
✓. Patients whose written ICF approved by the EC has been obtained, after having been duly informed of the nature of the study and voluntarily accepted to participate after being fully aware of the potential risks, benefits and any discomfort involved.

What they're measuring

clinical pregnancy rate

Timeframe: 3-5 weeks after embryo transfer

Trial details

NCT IDNCT05578456

SponsorSecond Affiliated Hospital, School of Medicine, Zhejiang University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-12-31

Contact for this trial

Min Jin, Doctor

+86-15925602121 min_jin@zju.edu.cn

View on ClinicalTrials.gov More Thyroiditis, Autoimmune trials