Health of Children Born From ICSI With AOA (AOA-BABIES) (NCT05578118) | Clinical Trial Compass
CompletedNot Applicable
Health of Children Born From ICSI With AOA (AOA-BABIES)
Vietnam63 participantsStarted 2022-10-23
Plain-language summary
The investigators follow up on the development of children born from ICSI-AOA using the Developmental Red Flags and Ages \& Stages Third Edition (ASQ-3) Questionnaires to give strong evidence about the safety of AOA in assisted reproductive technology.
Who can participate
Age range12 Months – 12 Months
SexALL
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Inclusion Criteria:
All single, live babies born following ICSI with AOA and ICSI without AOA from 08/2020 to 04/2021.
Parents consent to participate in the study. Group ICSI+AOA: Embryos from ICSI with AOA with calcium ionophore
In the ICSI+AOA group, indications of AOA are:
* Previous failed IVF treatment with no fertilization or poor fertilization rate (fertilized oocytes/pick-up oocytes\<35%) or poor embryo result (number of embryos/pick-up oocytes\<35%, \<3 embryos, no good-quality embryo)
* Using sperm after retrieval technique, cryptozoospermia Group Control: Embryos from ICSI without AOA.
In the Control group, the indications of AOA for the next IVF cycle (if patients continue the next IVF cycle) are:
* Currently failed IVF treatment with no fertilization or poor fertilization rate (fertilized oocytes/pick-up oocytes\<35%) or poor embryo result (number of embryos/pick-up oocytes\<35%, \<3 embryos, no good-quality embryo)
Exclusion Criteria:
Embryos with PGT. Oocyte donation