In this proposal, the investigators introduce a novel, translational study to prospectively examine primary brain tumor patients undergoing fractionated radiation therapy to the brain. Quantitative neuroimaging, radiation dose information, and directed neurocognitive testing will be acquired through this study to improve understanding of cognitive changes associated with radiation dosage to non-targeted tissue, and will provide the basis for evidence-based cognitive- sparing brain radiotherapy.
Age range
18 Years – 99 Years
Sex
ALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Longitudinal changes in imaging biomarker volume (cc) from volumetric MR imaging
Timeframe: baseline (pre-treatment), 3 months, 6 months, 12 months post-treatment
Longitudinal changes in imaging biomarker mean diffusivity (MD) in white matter from DTI imaging
Timeframe: baseline (pre-treatment), 3 months, 6 months, 12 months post-treatment
Longitudinal changes in imaging biomarker fractional anisotropy (FA) in white matter from DTI imaging
Timeframe: baseline (pre-treatment), 3 months, 6 months, 12 months post-treatment
Change in Memory after RT
Timeframe: baseline (pre-treatment), 3 months, 6 months, 12 months post-treatment
Change in Executive Functioning after RT
Timeframe: baseline (pre-treatment), 3 months, 6 months, 12 months post-treatment
Change in Attention/Processing Speed after RT
Timeframe: baseline (pre-treatment), 3 months, 6 months, 12 months post-treatment
Change in Language functioning after RT
Timeframe: baseline (pre-treatment), 3 months, 6 months, 12 months post-treatment
Change in Fine Motor Skills after RT
Timeframe: baseline (pre-treatment), 3 months, 6 months, 12 months post-treatment
Change in health-related quality of life (hrQoL) from baseline to 5 years after RT
Timeframe: baseline (pre-treatment), 3 months, 6 months, 12 months post-treatment