Effect and Tolerance of Standardized Exclusive Dry Extracts of Curcuma Longa and of Boswellia Serrata Among People With Hand Joint Discomfort and Dysfunction

Inclusion Criteria: * Body Mass Index ≤ 35 kg/m2 * Subjects that fulfil the following American College of Rheumatology (ACR) clinical criteria : * Hand pain, aching, or stiffness AND * 3 or 4 of the following features: * Hard tissue enlargement of 2 or more of 10 selected joints, * Hard tissue enlargement of 2 or more Distal interphalangeal (DIP) joints, * Fewer than three swollen metacarpophalangeal (MCP) joints, * Deformity of at least 1 of 10 selected hand joints. The 10 selected joints are the second and third Distal Interphalangeal joint (DIP), the second and third Proximal Interphalangeal joints (PIP), and the first carpometacarpal (CMC) joints of both hands. * Pain in hands at least half of the days in the previous month and for at least 48 h prior to the inclusion/baseline visit. * Finger pain score of 40-80 mm on a 100 mm Visual Analog Scale (VAS) on at least one hand over the last 24 hours. Subjects should respect a 24-hours wash-out period of authorized analgesic/anti-inflammatory medications (Paracetamol/oral NSAIDs) before the visit. * Willing to use only Paracetamol and oral NSAIDS as rescue treatment to manage hand pain during the study. Others analgesics and anti-inflammatory medication (oral and topic) are not allowed during the study and a wash out period of 5 half-life depending of the molecule should be respected before study entry. * Able to follow the instructions of the study * Having signed an informed consent Exclusion Criter…