In this study, we aimed to determine a specific cut-off value for 1mg DST to prevent false positivity usually seen in CRF patients according to the standard cut-off value of 1.8 mcg/dl.
Who can participate
Age range18 Years – 80 Years
SexALL
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Inclusion Criteria:
* Between 01 January 2018 and 31 December 2019, 2173 patients who were admitted to the outpatient clinic of our hospital's Endocrine and Metabolic Diseases Department and requested 1 mg DST were included in the screening.
Exclusion Criteria:
* Being under 18 years of age
* Liver cirrhosis and /or 3-fold or more increase in liver enzymes
* Use of drugs known to interact with dexamethasone (psychotropic agents, oral contraceptives, anti-epileptic drugs, barbiturates, etc.)
* An adrenal nodule or pituitary adenoma is detected, but it is at the stage of evaluation whether it is functional or not
* Typical CS clinical findings (such as Purple stria, Buffalo Hump, moon face)
* Having an adrenal nodule or pituitary adenoma and being followed by an external center
* Lack of access to be analyzed information in the study: Albumin, AST, ALT, creatine, white blood cell (WBC), C-Reactive Protein (CRP), glycosylated hemoglobin percentage (HBA1c), glucose, sodium, potassium, thyroid stimulating hormone (TSH), body mass index (BMI), known disease and drug use information, lipid profile tests and information, lack of access to the patient's previous data
* Having a diagnosis of severe major depression
* Previously diagnosed with Cushing Syndrome or operated with this diagnosis
* Prominent hypoalbuminemia (albumin \<3 g / dl)