Anti-Platelets in Chronic Obstructive Pulmonary Disease
United States19 participantsStarted 2024-03-27
Plain-language summary
This is a 6 week crossover study in current and former smokers with and without COPD to evaluate whether 2 weeks of dual antiplatelet therapy (aspirin 81mg and clopidogrel 75mg) improves pulmonary perfusion (i.e. blood flow in the lungs measured on a contrast CT scan) compared to placebo.
Who can participate
Age range50 Years – 80 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria - COPD Cases:
* COPD (FEV1/FVC \< 0.7, FVC \>= LLN), GOLD Stage I/II/III (FEV1 \>= 40%)
* Current or former smoker of at least 10 pack years
Inclusion Criteria - Controls:
* Normal lung function (FEV1/FVC \>= 0.7, FEV1 and FVC \>= LLN)
* Current or former smoker of at least 10 pack years
Exclusion Criteria:
* Platelet count \< 150,000/dL or self-report of a bleeding disorder;
* Regular use of aspirin, clopidogrel or another antiplatelet medication;
* Allergy to aspirin, clopidogrel, albuterol or iodine/IV contrast;
* BMI \> 35;
* History of intracranial hemorrhage, severe GI bleed or other life-threatening bleed;
* Use of blood thinner (e.g. warfarin, lovenox or novel oral anti-coagulants);
* Continuous use of supplemental oxygen at home;
* Regular use of an NSAID;
* Daily use of oral steroids, theophylline, roflumilast, or loop diuretics;
* History of organ transplant or autoimmune disease on systemic therapy (rheumatoid arthritis, lupus);
* Use of a biologic medication with regular injections;
* Other current lung disease (interstitial lung disease, idiopathic pulmonary fibrosis, asthma);
* IV drug use within the last year;
* History of lung surgery to remove part of the lung;
* Known bullae or advanced destructive emphysema in more than 1/3 of the lungs;
* Treatment for cancer (systemic therapy or surgical/radiation within the thorax) in the last 12 months;
* Known diagnosis of pulmonary hypertension;
* Known systolic heart failure (RV or LV EF \< 4…