Anti-Platelets in Chronic Obstructive Pulmonary Disease

Inclusion Criteria - COPD Cases: * COPD (FEV1/FVC \< 0.7, FVC \>= LLN), GOLD Stage I/II/III (FEV1 \>= 40%) * Current or former smoker of at least 10 pack years Inclusion Criteria - Controls: * Normal lung function (FEV1/FVC \>= 0.7, FEV1 and FVC \>= LLN) * Current or former smoker of at least 10 pack years Exclusion Criteria: * Platelet count \< 150,000/dL or self-report of a bleeding disorder; * Regular use of aspirin, clopidogrel or another antiplatelet medication; * Allergy to aspirin, clopidogrel, albuterol or iodine/IV contrast; * BMI \> 35; * History of intracranial hemorrhage, severe GI bleed or other life-threatening bleed; * Use of blood thinner (e.g. warfarin, lovenox or novel oral anti-coagulants); * Continuous use of supplemental oxygen at home; * Regular use of an NSAID; * Daily use of oral steroids, theophylline, roflumilast, or loop diuretics; * History of organ transplant or autoimmune disease on systemic therapy (rheumatoid arthritis, lupus); * Use of a biologic medication with regular injections; * Other current lung disease (interstitial lung disease, idiopathic pulmonary fibrosis, asthma); * IV drug use within the last year; * History of lung surgery to remove part of the lung; * Known bullae or advanced destructive emphysema in more than 1/3 of the lungs; * Treatment for cancer (systemic therapy or surgical/radiation within the thorax) in the last 12 months; * Known diagnosis of pulmonary hypertension; * Known systolic heart failure (RV or LV EF \< 4…