CompletedNot Applicable

A Real-world Comparison of FNB and FNA in IHC-required Lesions.

China439 participantsStarted 2014-12-01

Plain-language summary

Endoscopic ultrasound (EUS)-guided fine needles with side fenestrations are used to collect aspirates for cytology analysis and biopsy samples for histologic analysis. The investigators conducted a large, multicenter study to compare the accuracy of diagnosis via specimens collected with fine-needle biopsy (FNB) versus fine-needle aspiration (FNA) for patients with lesions requiring immunohistochemistry (IHC) pathological diagnosis.

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * age \>18 years; * presence of a solid mass lesion was confirmed by at least 1 imaging modality and it was located within pancreas, abdomen, mediastinum, or pelvic cavity; * mass size \>1 cm; * final diagnoses were obtained after surgery, imaging analysis, or resolution of the lesion, including AIP, NET, mesenchymal tumors, and lymphoma. Exclusion Criteria: * coagulopathy (international normalized ratio, 1.5); * thrombocytopenia (platelet count \<50,000/mm3); * acute pancreatitis within the previous 2 weeks; * inability to safely perform EUS-TA (eg, cardiorespiratory dysfunction, mental diseases, or drug addiction); * refusal or inability to provide an informed consent.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Diagnostic yields of EUS-FNA with EUS-FNB for solid masses

Timeframe: From admission until the date of pathological diagnosis obtained or follow-up up to 24 months

Diagnostic yields of EUS-FNA with EUS-FNB for solid masses

Timeframe: From admission until the date of pathological diagnosis obtained or follow-up up to 24 months

Diagnostic yields of EUS-FNA with EUS-FNB for solid masses

Timeframe: From admission until the date of pathological diagnosis obtained or follow-up up to 24 months

Diagnostic yields of EUS-FNA with EUS-FNB for solid masses

Timeframe: From admission until the date of pathological diagnosis obtained or follow-up up to 24 months

Trial details

NCT IDNCT05565066

SponsorHuazhong University of Science and Technology

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2022-09-30

View on ClinicalTrials.gov More Neuroendocrine Tumors trials

Plain-language summary

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Diagnostic yields of EUS-FNA with EUS-FNB for solid masses

Timeframe: From admission until the date of pathological diagnosis obtained or follow-up up to 24 months

Diagnostic yields of EUS-FNA with EUS-FNB for solid masses

Timeframe: From admission until the date of pathological diagnosis obtained or follow-up up to 24 months

Diagnostic yields of EUS-FNA with EUS-FNB for solid masses

Timeframe: From admission until the date of pathological diagnosis obtained or follow-up up to 24 months

Diagnostic yields of EUS-FNA with EUS-FNB for solid masses

Timeframe: From admission until the date of pathological diagnosis obtained or follow-up up to 24 months