RecruitingNot Applicable

Sedation, Temperature and Pressure After Cardiac Arrest and Resuscitation

Australia3,500 participantsStarted 2023-08-17

Plain-language summary

The STEPCARE-trial is a 2x2x2 randomised trial studying patients who have been resuscitated from cardiac arrest and who are comatose. It will include three different interventions focusing on sedation targets, temperature targets and mean arterial pressure targets.

Who can participate

Age range18 Years

SexALL

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Inclusion criteria

✓. Out-of-hospital cardiac arrest
✓. Sustained ROSC - defined as 20 minutes with signs of circulation without the need for chest compressions
✓. Unconsciousness defined as not being able to obey verbal commands (FOUR-score motor response of \<4) or being intubated and sedated because of agitation after sustained ROSC.
✓. Eligible for intensive care without restrictions or limitations
✓. Inclusion within 4 hours of ROSC

Exclusion criteria

✕. On ECMO prior to randomization
✕. Pregnancy
✕. Suspected or confirmed intracranial hemorrhage
✕. Previously randomized in the STEPCARE trial
✕. Trauma or hemorrhage being the presumed cause of arrest

What they're measuring

Mortality

Timeframe: 6 months

Trial details

NCT IDNCT05564754

SponsorRegion Skane

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-12

Contact for this trial

Josef Dankiewicz, PhD

+464671000 josef.dankiewicz@med.lu.se

View on ClinicalTrials.gov More Cardiac Arrest With Successful Resuscitation trials