Repeat Dose Steroid to Prevent Pain Relapse After Total Knee Arthroplasty in Patients With High Pain Response

Inclusion Criteria: * Age ≥ 40 years. * Primary unilateral TKA. * Ability to participate in the study (understand written and spoken Danish language, self-reported pain and satisfaction). * Signed written informed consent form. * PCS \>20. * Moderate to severe postoperative pain (VAS \>30) in a 5-meter walk test 22-26 hours after end of surgery. Exclusion Criteria: * Ongoing treatment of systemic glucocorticoids or other immunosuppressant treatment apart from inhaled steroids. * Insulin-dependent diabetes. * Pregnancy or breastfeeding.\* * Allergies concerning the study-drug. * Mental disability that could impair a patient's decision-making capability of giving informed consent and not enabling valid data collection. * Patients with known diagnoses of schizophrenia, ongoing psychosis, bipolar disease and/or a history of ongoing anti-psychotic treatment. * Patients with modulated pain-reception (experience) based on other diseases or injuries, e.g. spinal cord or brain injury, severe polyneuropathies or neurologic disorders. * Peripheral nerve block per- or postoperatively. * Pregnancy: No women with suspected or proven pregnancy are eligible for inclusion. The following will be considered as safe contraception: intrauterine device or hormonal contraception. For women aged between 40-50 years, a urine HCG test for pregnancy will be performed.