Clavulanic Acid for the Treatment of Cocaine Use Disorder

Inclusion Criteria: * Be able to verbalize understanding of consent form, able to provide written informed consent, and verbalize willingness to complete study procedures * Be male or female adult volunteers ages 18-70 inclusive. * Have a Diagnostic and Statistical Manual (DSM-V) diagnosis of cocaine use disorder, moderate to severe in early remission with a duration of regular (weekly or more) cocaine (either snorted, smoked or injected) for at least one year. * Have a history and brief physical examination that demonstrate no clinically significant contraindication for participating in the study, and/ or significant or unstable medical or psychiatric illness. Exclusion Criteria: * Meets DSM-V criteria for dependence on any substance other than cocaine and mild to moderate alcohol or marijuana (except nicotine or caffeine), determined by the structured clinical interview for DSM-V. * Allergy to clavulanic acid, penicillin, or any beta-lactam drug. * Meets current or lifetime DSM-V criteria for schizophrenia or any psychotic disorder or organic mental disorder. Subject meets current DSM-V diagnosis of any other clinically significant psychiatric disorder that will interfere with study participation. * Severe physical or medical illnesses such as AIDS or active hepatitis. * If female, tests positive on a pregnancy test, is contemplating pregnancy in the next 6 months, is nursing, or is not using an effective contraceptive method (if relevant)