Characteristics of the Anosmic Olfactory Mucosa (NCT05562050) | Clinical Trial Compass
Active — Not RecruitingNot Applicable
Characteristics of the Anosmic Olfactory Mucosa
Denmark18 participantsStarted 2023-11-01
Plain-language summary
The present study aims to describe the structural tissue and cell characteristics of the olfactory mucosa in patients with persistent anosmia (≥2 years) due to COVID-19 or head-trauma, in comparison to healthy individuals with intact olfactory function. In order to avoid possible age-related degenerative changes in the neuro-epithelium, both patients and controls are between 25 and 35 years of age.
Who can participate
Age range25 Years – 35 Years
SexALL
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Inclusion criteria
✓. Diagnosed with persistent anosmia for approximately two years concurring with positive SARS-CoV-2 PCR-test between 2019 and 2020.
✓. Sniffin'sticks test with a threshold-discrimination-identification-score(TDI)≤16
✓. Between 25 and 35 years of age.
✓. Diagnosed with persistent anosmia for approximately two years concurring with head trauma.
✓. Sniffin'sticks test with a threshold-discrimination-identification-score(TDI)≤16
✓. Between 25 and 35 years of age.
✓. Between 25 and 35 years of age.
✓. Undergoing reposition of a nasal fracture in general anaesthesia
Exclusion criteria
✕. Anosmia for less than two years or more than two and a half years.
✕. No positive SARS-CoV-2 PCR-test concurring with olfactory dysfunction.
✕. History of olfactory dysfunction before COVID-19 infection.
✕. Anosmia for less than two years or more than approximately two-three years.