CompletedNot Applicable

Prediction of Non-motor Symptoms in Fully Ambulatory MS Patients Using Vocal Biomarkers

Switzerland70 participantsStarted 2022-07-15

Plain-language summary

The investigator will set up a study evaluating vocal biomarkers in people with MS in order to identify persons with non-motor symptoms: depression, cognitive deterioration, and fatigue. Up to now, to the best of the investigator's knowledge, there is no study reporting the use of vocal biomarkers to predict these three non-motor symptoms in people with MS.

Who can participate

Age range18 Years – 60 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Relapsing MS * Age over 18 * EDSS \< 4.0 * Capability of written informed consent Exclusion Criteria: * Not fluent in german language * Relapse or Steroids per os/intra venous \< 4 weeks prior to examination * KM enhancing lesion in MRI \< 4 weeks prior to examination * Other previous disease affecting the speech * Pregnant patients * Mental disability and not able to understand the protocol and study tasks in german languagePatients with greater physical and cognitive disability or history of major depressive disorder and suicide attempt/suicidal thoughts * Patients with sleep disorders and comorbidities associated with extreme fatigue (e.g., fibromyalgia)

What they're measuring

Identification of a voice signature that separates between pwMS with and without fatigue

Timeframe: One year

Trial details

NCT IDNCT05561621

SponsorInsel Gruppe AG, University Hospital Bern

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2022-12-20

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