CompletedNot Applicable

Intrathecal Dexamethasone and Atropine on Morphine Induced Post-operative Nausea and Vomiting on Caesarean Section

Egypt150 participantsStarted 2022-10-01

Plain-language summary

Pain is a major problem during the postoperative period and can be considered as a challenge for the anesthesiologist. Low dose intrathecal morphine is proven efficient as a mode to reduce postoperative pain. Morphine has many complications like post-operative nausea and vomiting (PONV). the investigators will investigate the utility of intrathecal (IT) atropine and dexamethasone for prevention of morphine induced PONV as a primary outcome in parturient undergoing CS under spinal bupivacaine anesthesia plus morphine sulfate as an adjuvant.

Who can participate

Age range18 Years – 45 Years

SexFEMALE

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Inclusion criteria

✓. Female
✓. 18-45 years old
✓. ASA: 1, 2
✓. Elective caesarean section under spinal anaesthesia.

Exclusion criteria

✕. Patient refusal.
✕. Contraindications to spinal anaesthesia as coagulopathy, infection at site of injection, hemodynamic instability and uncooperative patient.
✕. Contraindications to administration of morphine as asthmatic patient and hypersensitivity and contraindications to any of the study drugs.
✕. Adult-Emergency CS as there is no time for preparation and risk on fetus and mother for time consuming

What they're measuring

Incidence and severity of PONV

Timeframe: 24 hour

Trial details

NCT IDNCT05560542

SponsorAssiut University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-03-01

View on ClinicalTrials.gov More Morphine Adverse Reaction trials