Needle-Based Confocal Laser Endomicroscopy for Diagnosis of Lung Cancer in Patients With Peripheral Pulmonary Nodules

Inclusion Criteria: * \>= 21 years of age * Suspected PPN * Nodule size in computed tomography (CT) between 8 mm and 30 mm (largest dimension) * Ability to understand and willingness to sign a written informed consent and Health Insurance Portability and Accountability Act (HIPAA) consent document Exclusion Criteria: * Inability or non-willingness to provide informed consent * Failure to comply with the study protocol * Patients with known allergy for fluorescein or risk factors for an allergic reaction * Use of beta-blocker within 24 hours before the start of the bronchoscopic procedure * Possibly pregnant, pregnant or breastfeeding women * Patients with hemodynamic instability * Patients with refractory hypoxemia * Patients with a therapeutic anticoagulant that cannot be held for an appropriate interval before the procedure * Patients who are unable to tolerate general anesthesia according to the anesthesiologist * Patient undergoing chemotherapy * INTRA-OPERATIVE EXCLUSION/STOPPING CRITERIA: * The lesions are unable to be localized/confirmed by bronchoscopy * The procedure will be terminated if the patient develops a significant procedural complication as determined by the treating physician * The procedure will be terminated if the patient develops hemodynamic instability as determined by the treating physician