Preventing Recurrent UTI With Vaginal Estrogen

Inclusion Criteria: Participants in this study will be * Postmenopausal women (menopausal for at least 1 year) * Minimum age of 55 years * Participants will have documentation of recurrent UTI, defined as follows: * History of treatment for at least 3 UTIs in the past year or 2 episodes within 6 months AND * At least one positive urine culture during an acute symptomatic episode. Exclusion Criteria: * Women receiving antibiotic prophylaxis to prevent UTI recurrence; * Women with contraindications to vaginal estrogen (as indicated on the FDA-mandated package insert) and those who have used vaginal or systemic estrogen within the past 6 months; * Women with an active UTI and those who have received antibiotics within the prior 2 weeks; * Women with complicated rUTI, defined by immune compromise, anatomic or functional abnormalities of the urinary tract, indwelling catheterization, those performing self-catheterization, and those with neurological disease or illness relevant to the lower urinary tract; * Women with only asymptomatic bacteriuria (rather than recurrent symptomatic UTI)