Safety, Tolerability and Pharmacodynamics of AZR-MD-001 in Contact Lens Discomfort (CLD)

Inclusion Criteria: * Evidence of meibomian gland obstruction (based on a meibomian gland secretion (MGS) score of ≤12 for 15 glands of the lower lid) in both eyes. * A history of wearing soft contact lenses for at least 6 months. * Screening CLDEQ-8 score \>12 Exclusion Criteria: * Active ocular infection (bacterial, viral, or fungal). * Participant is unlikely to follow study instructions or to complete all required study visit(s) or has a condition or situation that in the investigator's opinion, may put the participant at significant risk, may confound the study results, or may interfere significantly with the participant's participation in the study. * Participant is an employee at the investigational site or is related to any member of the study staff. * Participation in another clinical trial involving a therapeutic drug or device within the past 30 days