UnknownNot Applicable

Implantation of Capsular Tension Ring in Primary Angle Closure Patients With Zonular Laxity or Dialysis

China156 participantsStarted 2023-03-01

Plain-language summary

Primary angle closure glaucoma (PACG) is the main type of glaucoma in China, which includes acute and chronic PACG. According to the International Society of Geographical and Epidemiological Ophthalmology (ISGEO), this spectrum of disease is divided into acute angle closure crisis (AACC), primary angle closure suspect (PACS), primary angle closure (PAC) and PACG. Previous researchers have reported that with the wider use of lens extraction and intraocular lens (IOL) implantation combined with anti-glaucoma surgery in the treatment of PAC and PACG, the prevalence of zonular laxity or dialysis in primary angle closure disease (PACD) was found to be relatively high. In one of the studies performed by the investigators, the proportion of zonular laxity or dialysis was 46.2%, significantly higher than that in the age-related cataract patients (control group), which was 6.0%. In PACD patients with zonular laxity or dialysis, whether or not should the investigators implant capsular tension ring (CTR), the efficacy and safety of CTR implantation, and if there is any difference in the prevalence of complications during and after surgery between patients with and without CTR implantation remain unclear. The purpose of this study was to investigate the efficacy and safety of CTR implantation in PACD patients with zonular laxity and zonular dialysis ≤ 4 clocks.

Who can participate

Age range45 Years – 79 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age: 45-79 years old * Continuous cases diagnosed with AACC, PACS, PAC and PACG in glaucoma department of Beijing Tongren Hospital from October 1st, 2022 to December 31th, 2024 and undergo phacoemulsification lens extraction and intraocular lens implantation combined with goniosynechialysis * Wrinkling of the anterior capsule during manual continuous circular capsulorhexis (CCC) but without infolding of peripheral capsule or visualization of the capsular equator, or, wrinkling of the anterior capsule during manual capsulorhexis and combined with visualization of capsular equator and infolding of peripheral capsule ≤ 4 clocks (lens subluxation) * The eye of each subject that meet the inclusion criteria is included and if both eyes meet the inclusion criteria, the first eye that undergo the surgery is included Exclusion Criteria: * Past history of intraocular surgeries including trabeculectomy, peripheral iridotomy, glaucoma valve implantation, vitrectomy, and so on * Past history of laser peripheral iridotomy or iridoplasty * Past history of ocular trauma or signs referring to ocular trauma * Ocular diseases that may cause zonulopathy, including choroidal detachment, retinal detachment, ciliary body detachment, intraocular tumor and so on * Lens related secondary glaucoma, including spherophakia, Marfan syndrome, homocystinuria and son on * Other secondary angle closure glaucoma, including neovascular glaucoma, iritis related secondary glaucoma and so …

What they're measuring

Spherical equivalent

Timeframe: baseline

Spherical equivalent

Timeframe: 1 month after the surgery

Spherical equivalent

Timeframe: 3 months after the surgery

Spherical equivalent

Timeframe: 6 months after the surgery

Spherical equivalent

Timeframe: 12 months after the surgery

Area of anterior capsulorhexis

Timeframe: 1 week after the surgery

Area of anterior capsulorhexis

Timeframe: 1 month after the surgery

Area of anterior capsulorhexis

Timeframe: 3 months after the surgery

Area of anterior capsulorhexis

Trial details

NCT IDNCT05542290

SponsorBeijing Tongren Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-10-01

Contact for this trial

Chunyan Qiao, M.D.

86-17610678637 chunyan_qiao@163.com

View on ClinicalTrials.gov More Glaucoma trials

Plain-language summary

Who can participate

Age range45 Years – 79 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Spherical equivalent

Timeframe: baseline

Spherical equivalent

Timeframe: 1 month after the surgery

Spherical equivalent

Timeframe: 3 months after the surgery

Spherical equivalent

Timeframe: 6 months after the surgery

Spherical equivalent

Timeframe: 12 months after the surgery

Area of anterior capsulorhexis

Timeframe: 1 week after the surgery

Area of anterior capsulorhexis

Timeframe: 1 month after the surgery

Area of anterior capsulorhexis

Timeframe: 3 months after the surgery

Area of anterior capsulorhexis