UnknownNot Applicable

Coeliac Plexus Neurolysis Versus Splanchnic Nerve Neurolysis

Hong Kong100 participantsStarted 2022-12-01

Plain-language summary

Pain is prevalent among patients with gastrointestinal cancers. Standard procedures such as coeliac plexus neurolysis (CPN) is effective in reducing pain, opioid requirement and related side effects for pancreatic cancer cases. Meanwhile, splanchnic nerve neurolysis (SNN) as an alternative to CPN is more effective for cancer pain relief. Although previous studies investigating the role of CPN/SNN mainly focus on pancreatic cancer cases, their efficacy on non-pancreatic abdominal cancer pain may not be accurately determined.

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age\>=18 * Diagnosis of unresectable intra-abdominal cancer * Visceral pain attributable to the cancer with NRS \>= 4 * Able to understand instructions, give consent, complete questionnaires Exclusion Criteria: * Primary pancreatic cancer or metastatic disease involving pancreas * Gross celiac axis distortion identified on imaging * Acute abdomen condition eg. Intraabdominal sepsis, tumor rupture * Other non-cancer causes attributable to the pain * Gross ascites * Previous coeliac plexus or splanchnic nerve neurolysis * Contraindications to neurolytic procedures eg. Bleeding tendency; local or systemic infections; allergic to local anesthetics, contrast or alcohol; intestinal obstruction; anatomical distortion along needle trajectory * Patients believed to be inappropriate for study by investigators

What they're measuring

pain score

Timeframe: at one week after procedure

Trial details

NCT IDNCT05541211

SponsorThe University of Hong Kong

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2024-09-30

Contact for this trial

Timmy CW Chan, MBBS

22555791 timmychancw@gmail.com