Muscle Recovery After Critical Illness (NCT05537298) | Clinical Trial Compass
RecruitingNot Applicable
Muscle Recovery After Critical Illness
United States209 participantsStarted 2022-10-18
Plain-language summary
The overarching goal of the proposed study is to determine the trajectories of physical recovery and cellular markers involved with the underlying failure to recover muscle after critical illness, while exploring which characteristics are associated with sustained physical disability. This proposal will examine muscle pathophysiology carefully aligned with physical function outcomes in order to longitudinally assess the recovery, or failed recovery, of muscle function in participants after critical illness:
1. to examine the recovery of muscle and physical function in ICU survivors through longitudinal assessments
2. to investigate the underlying cellular markers and mechanisms of muscle recovery in ICU survivors
3. to determine which cellular markers contribute to physical disability in ICU survivors up to 1 year after hospital admission
Who can participate
Age range
18 Years
Sex
MALE
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* adult (\>18 y/o)
* admission for sepsis or acute respiratory failure with at least 72 hour stay in ICU
Exclusion Criteria:
* patients who were not ambulatory prior to ICU admission
* experienced \>2 ICU admissions in the past year (chronic or recurrent critical illness due to the same or different reason
* patients not expected to survive \~6months after admission
* acute or chronic neurologic condition
* acute or chronic orthopedic condition preventing strength/functional testing
* morbid obesity \>50 kg/m2 due to distortion of muscle ultrasonography
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial is focused on muscle recovery after critical illness — given my specific situation in the ICU, does my doctor think I'm likely to experience the kind of muscle weakness this study is targeting, and would participating help us understand what's happening in my muscles?
2The trial is measuring mitochondrial function alongside physical function and muscle power — can my doctor explain what that means in plain terms, and why understanding mitochondrial health might matter for my recovery after a critical illness?
3Since this trial doesn't have a traditional phase number, what does that tell us about what's already known versus what the researchers are still trying to figure out, and how does that affect any risks or benefits for me if I participate?
4What kinds of tests or procedures would I need to go through to measure my muscle power and mitochondrial function — and given how physically demanding recovery from critical illness already is, would my doctor think I'm in a realistic position to handle the demands of this study?
5Are there standard rehabilitation approaches or treatments for ICU-acquired weakness that my doctor would recommend I pursue first, or alongside this trial, rather than waiting to see what the study finds?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.