CompletedNot Applicable

Physiologic Mechanisms Underlying Ovarian Follicular Waves During the Menstrual Cycle

Canada50 participantsStarted 2022-09-17

Plain-language summary

The research aims to characterize changes in ovarian and pituitary hormones associated with the development of ovarian follicular waves during the human menstrual cycle.

Who can participate

Age range18 Years – 40 Years

SexFEMALE

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Healthy biological females * Regular menstrual cycles (21-35 days) Exclusion Criteria: * BMI \<18 or \>30 * Pregnancy * Breastfeeding mothers * Current infertility * History of hysterectomy or oophorectomy * Reproductive health issues that can interfere with study outcomes * Smoking * Metabolic syndrome (blood pressure, fasting glucose, fasting insulin and serum lipids measured to assess eligibility) * Not on any hormonal medication that affects reproduction (including hormonal contraception) * Hyperprolactinemia * Abnormal thyroid stimulating hormone assay

What they're measuring

Antral follicle diameter

Timeframe: One menstrual cycle (21-35 days) per volunteer

Antral follicle count

Timeframe: One menstrual cycle (21-35 days) per volunteer

Follicle stimulating hormone (FSH) serum level

Timeframe: One menstrual cycle (21-35 days) per volunteer

Luteinizing hormone (LH) serum level

Timeframe: One menstrual cycle (21-35 days) per volunteer

Estradiol serum level

Timeframe: One menstrual cycle (21-35 days) per volunteer

Progesterone serum level

Timeframe: One menstrual cycle (21-35 days) per volunteer

Anti-mullerian hormone (AMH) serum level

Timeframe: One menstrual cycle (21-35 days) per volunteer

Inhibin A serum level

Timeframe: One menstrual cycle (21-35 days) per volunteer

Trial details

NCT IDNCT05531357

SponsorUniversity of Saskatchewan

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2024-03-26

View on ClinicalTrials.gov More Reproductive Issues trials

Who can participate

Age range18 Years – 40 Years

SexFEMALE

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Antral follicle diameter

Timeframe: One menstrual cycle (21-35 days) per volunteer

Antral follicle count

Timeframe: One menstrual cycle (21-35 days) per volunteer

Follicle stimulating hormone (FSH) serum level

Timeframe: One menstrual cycle (21-35 days) per volunteer

Luteinizing hormone (LH) serum level

Timeframe: One menstrual cycle (21-35 days) per volunteer

Estradiol serum level

Timeframe: One menstrual cycle (21-35 days) per volunteer

Progesterone serum level

Timeframe: One menstrual cycle (21-35 days) per volunteer

Anti-mullerian hormone (AMH) serum level

Timeframe: One menstrual cycle (21-35 days) per volunteer

Inhibin A serum level

Timeframe: One menstrual cycle (21-35 days) per volunteer