Life-style Interventions for Modulating the Brain Phenotype of Takotsubo Cardiomyopathy

Inclusion Criteria: * Patients diagnosed with takotsubo cardiomyopathy in the previous three weeks * Participant who is willing and able to give informed consent for participation in the study. * Participant who is willing to travel to Aberdeen Royal Infirmary for the study visits. * Healthy volunteers (for blood and saliva samples only) willing to give informed consent for participation in the study. Healthy volunteers should not be on any medication. * For influenza T-Cell testing: healthy volunteers who have recently received their annual flu vaccination. * Myocardial Infarction (MI) comparators: patients with type 1 acute MI (diagnosed within the last three weeks) Exclusion Criteria: * Any patient whose takotsubo cardiomyopathy was triggered by a physical illness that would preclude them from taking part in a physical exercise training program * Any patient who is not able or willing to travel to the cardiovascular research facility for their study visits * Any patient who is not able to commit to a 12 week supervised training program * Inability to exercise on a cycle ergometer or a treadmill (e.g. use of walking aids or prosthetic limbs or advanced frailty) * Unwillingness to participate * Contraindication to MRI scanning such as implantable cardiac devices. * Pregnancy * Healthy volunteers taking medication