The Immunological Differences Between Fournier Gangrene and Perianal Abscess (NCT05529628) | Clinical Trial Compass
CompletedNot Applicable
The Immunological Differences Between Fournier Gangrene and Perianal Abscess
Turkey (Türkiye)49 participantsStarted 2022-01-01
Plain-language summary
Although it is rarely observed, necrotizing fasciitis progresses with high mortality and serious complications. Fournier's gangrene is a specific form of necrotizing fasciitis. In laboratory tests, leukocytosis or leukopenia, anemia, lymphopenia can be observed. Perianal abscess is a surgical emergency that is observed much more frequently than necrotizing fasciitis. Although Fournier's gangrene has many different etiologies, it rarely occurs due to the progression of perianal abscess, and although it is difficult to distinguish between these two diseases at diagnosis, the two diseases manifest themselves as different entities. In this study, blood cytokine levels will be evaluated in patients with Fournier's gangrene and perianal abscess, and the role of blood cytokine levels in the differential diagnosis of these two diseases will be investigated.
Who can participate
Age range
18 Years – 88 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Patients applying to the emergency department with Fournier's gangrene and perianal abscess.
Exclusion Criteria:
* Patients with primary immunodeficiency
* Crohn's patients
* HIV patients,
* Cancer patients,
* Pregnancy,
* Patients younger than 18 years and older than 88 years
* Patients who did not agree to participate in the study
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This study compared immune system markers called cytokines in people with Fournier gangrene versus perianal abscess — can you explain what that difference might mean for understanding my diagnosis or how severe my condition is?
2Since this trial is already completed, have the results been published yet, and is there anything in the findings that could influence how you would treat my specific situation?
3I understand this was an observational study measuring biological signals rather than testing a new treatment — does that mean my care would be managed with standard treatment approaches, and what does that currently look like for Fournier gangrene or perianal abscess?
4Fournier gangrene and perianal abscess can look similar early on but have very different outcomes — are there cytokine or immune markers from studies like this one that doctors are starting to use in practice to tell them apart more quickly?
5Given that this study was focused on understanding the immune response rather than testing a drug or procedure, should I also be looking into other trials that are actually testing new treatments for my condition?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.