CompletedNot Applicable

Sex Differences in Sympathetic Vascular Reactivity at High Altitude

Canada17 participantsStarted 2022-07-28

Plain-language summary

This study aims to investigate sex differences in blood pressure control associated with exposure to acute hypoxia (low oxygen), and short term acclimatization to hypoxia at high altitude.

Who can participate

Age range

18 Years – 45 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Between ages of 18-50 * No medical history of cardiovascular, respiratory, nervous system, or metabolic disease * Females must be pre-menopausal Exclusion Criteria: * Any known cardiovascular, respiratory, nervous system, or metabolic disease (however, participants with controlled arterial hypertension will not be excluded) * Having travelled above 2,000m within 1 month of testing at low and high altitude * Females who are pregnant, confirmed by a pregnancy test * Females who are post-menopausal * Participants that are classified as obese (body mass index \> 30kg⋅m²) * Participants who are current daily smokers * Those with a known allergy to sulfites * Participants taking monoamine oxidase (MAO) inhibitors or tricyclic antidepressants or other medications that have contraindications with the study drugs * Participants who are still within the washout period from participating in other studies involving drugs.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Change in systolic, diastolic, and mean arterial blood pressure

Timeframe: 3 minutes

Change in arterial blood flow

Timeframe: 1 hour 30 minutes

Change in vascular conductance

Timeframe: 20 minutes

Cold pressor test

Timeframe: 3 minutes

Propranolol

Timeframe: 2 hours

Phentolamine

Timeframe: 1 hour

Trial details

NCT IDNCT05525416

SponsorUniversity of Alberta

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2023-02-05

View on ClinicalTrials.gov More Vasodilation trials

Who can participate

Age range

18 Years – 45 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.