Sex Differences in Sympathetic Vascular Reactivity at High Altitude

Inclusion Criteria: * Between ages of 18-50 * No medical history of cardiovascular, respiratory, nervous system, or metabolic disease * Females must be pre-menopausal Exclusion Criteria: * Any known cardiovascular, respiratory, nervous system, or metabolic disease (however, participants with controlled arterial hypertension will not be excluded) * Having travelled above 2,000m within 1 month of testing at low and high altitude * Females who are pregnant, confirmed by a pregnancy test * Females who are post-menopausal * Participants that are classified as obese (body mass index \> 30kg⋅m²) * Participants who are current daily smokers * Those with a known allergy to sulfites * Participants taking monoamine oxidase (MAO) inhibitors or tricyclic antidepressants or other medications that have contraindications with the study drugs * Participants who are still within the washout period from participating in other studies involving drugs.