In this project, the aim is to recruit patients with drug resistant epilepsy and those suffering from migraine. Interestingly, patients suffering from epilepsy are also more often reporting to suffer from migraine. The pathobiology is understudied, but it is believed that both etiologies results from brain networks changes. A clinical certified 7T Terra Siemens scanner will be employed to assess in all participants (including healthy controls) how the microstructure differs in disease specific areas. Patients will further be clinically assessed as well as undergo questionnaires. Migraine is also a common comorbidity to visual snow syndrom and has been shown to impact similar brain regions. However, the pathophysiology is still understudied and a better understanding of the two diseases is needed.
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
MR: multi-parameter mapping (MPM)
Timeframe: Once during visit 2 (1-2 weeks after visit 1)
MR: quantitative susceptibility mapping (QSM)
Timeframe: Once during visit 2 (1-2 weeks after visit 1)
Resting-state fMRI (brain and brainstem/spinal cord)
Timeframe: Once during visit 2 (1-2 weeks after visit 1)
MR: whole-brain structural scans
Timeframe: Once during visit 2 (1-2 weeks after visit 1)
MR: routine clinical scans
Timeframe: Once during visit 2 (1-2 weeks after visit 1)
MR spectrosocpy
Timeframe: Once during visit 2 (1-2 weeks after visit 1)
MR: diffusion imaging
Timeframe: Once during visit 2 (1-2 weeks after visit 1)
MR: axial T2*w sequence
Timeframe: Once during visit 2 (1-2 weeks after visit 1)
Task-fMRI
Timeframe: Once during visit 2 (1-2 weeks after visit 1)