By InvitationNot Applicable

Gene Expression in Lower Extremity Acute Traumatic Compartment Syndrome

United States80 participantsStarted 2022-06-10

Plain-language summary

The purpose of this study is to evaluate both genotypic differences and differences in local gene expression in individuals who develop acute traumatic compartment syndrome relative to control patients with at-risk lower extremity fractures who do not develop compartment syndrome.

Who can participate

Age range18 Years – 90 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Patient 18+ years of age. English speaking. * Patients with the clinical diagnosis of lower leg acute compartment syndrome secondary to tibial shaft or tibial plateau fracture. * Patients without clinical compartment syndrome undergoing operative intervention within 48 hours of injury for tibial shaft or tibial plateau fractures. * Patients with the clinical diagnosis of exertional compartment syndrome with planned surgical intervention. Exclusion Criteria: * Non-english speaking participants

What they're measuring

Myostatin (% increase)

Timeframe: Immediately after the muscle tissue harvest procedure.

Trial details

NCT IDNCT05521958

SponsorUniversity of Utah

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2028-06

View on ClinicalTrials.gov More Tibial Shaft Fracture trials