Safety and Efficacy of PDT vs RFA vs PDT+RFA for the Treatment of Extrahepatic Cholangiocarcinoma

Inclusion Criteria: * Histologically or cytologically confirmed cholangiocarcinoma; * unresectable cholangiocarcinoma due to local infiltration of major vessels according to computed tomography (CT), magnetic resonance cholangiopancreatography (MRCP), or endoscopic ultrasound（EUS）; * No previous treatment; * Adequate bone marrow and organ function (white blood cells\>4.0×109/L, hemoglobin\>90 g/L, and platelets\>75×109/L, serum creatinine\<2.0 mg/dl); * A Karnofsky performance status (KPS) score ≥ 50; * Signed written informed consent. Exclusion Criteria: * Imaging examination (CT, MRCP, EUS) showed distant metastasis of liver, lung and other organs; * Coexistent with other malignant tumors; * Pregnant or nursing women; * Previous gastrointestinal diversion; * Participation in another study during the month before enrollment in this study; * Alcohol and/or substance abuse or potentially poor compliance per a doctor's judgment.