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Dysautonomia and Systemic Interactions in Traumatic Brain Injury

Sweden24 participantsStarted 2019-08-01

Plain-language summary

Following brain injury, complex interactions between the nervous system and other organs are frequently encountered. Systemic effects may be induced by dysregulation of the hypothalamic-pituitary-adrenal axis and the autonomic nervous system. This observational study will investigate the link between clinical, physiological and biochemical expressions of dysautonomic reactions and physiological stress, and their relations to sympathetic activation in traumatic brain injury patients treated in the neurointensive care unit.

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age 18 years or over. * Patients suffering from TBI, in need of neurocritical care and intracranial pressure measurement Exclusion Criteria: * Trauma more than 24 hours prior to inclusion. Goal for inclusion is less than 12 hours. * TBI unlikely to survive five days (as judged by clinical team, such as bilateral fixed and dilated pupils). * Follow up not possible

What they're measuring

Skin Conductance Algesimeter

Timeframe: up to one week

Stress biomarkers

Timeframe: up to one week in ICU

Trial details

NCT IDNCT05515640

SponsorKarolinska University Hospital

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2024-06

View on ClinicalTrials.gov More Traumatic Brain Injury trials