Given the clinical need to improve upon current antibiotic regimens for the treatment of C. difficile infection with a particular focus on the impact of therapies on gut microbiome, this study proposes to characterize the impact of Intravenous (IV) omadacycline on gut microbiome of healthy volunteers.
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Phylum Level Mean Proportional Relative Abundance
Timeframe: Day 30
Phylum Level Mean Proportional Relative Abundance
Timeframe: Baseline
Phylum Level Mean Proportional Relative Abundance
Timeframe: Day 5
Phylum Level Mean Proportional Relative Abundance
Timeframe: Day 10
Bacterial DNA Per Gram of Stool
Timeframe: Baseline
Bacterial DNA Per Gram of Stool
Timeframe: During Therapy up to Day 6
Bacterial DNA Per Gram of Stool
Timeframe: End of Therapy up to Day 10
Order Level Mean Proportional Relative Abundance
Timeframe: Baseline
Order Level Mean Proportional Relative Abundance
Timeframe: Day 5
Order Level Mean Proportional Relative Abundance
Timeframe: Day 10
Order Level Mean Proportional Relative Abundance
Timeframe: Day 30