MIBG in Aging and Neurologic Disorders

Inclusion Criteria * Diagnosis of one of the syndromes/diagnoses of interest using established criteria * STMS score above 10 * No active medical disorder that could preclude participation * Stable medication regimen over previous four weeks * Absence of certain medications that could significantly impact the myocardial 123I-MIBG scintigraphy findings * For those with dementia, caregiver that is with the patient at least 4 hours/day for at least 5 days per week * For those with dementia, or severe parkinsonism, patient and caregiver willing and able to participate in all study-related procedures * Patient is capable of giving informed consent, or if appropriate, has caregiver capable of giving consent on the subject's behalf. Exclusion Criteria * Does not fulfill criteria for any of the desired diagnoses * Women with intact uterus and not post-menopausal unless pregnancy test performed at screening is negative * Women who are pregnant or are breast-feeding an infant * STMS score \<10 * Active medical disorder that could preclude participation in this protocol * Hypersensitivity to the radioligand or iodine * Myocardial infarction or cerebral infarct over preceding year, stable or unstable angina, known symptomatic coronary artery disease * Renal disease viewed by the physician to be too severe to warrant myocardial 123I-MIBG scintigraphy imaging * History of significant alcohol or drug abuse * Any other medical disorder considered by the study physicians as inap…