B-cell Lymphoma is an aggressive and rare cancer of a type of immune cells (a white blood cell responsible for fighting infections). Follicular Lymphoma is a slow-growing type of non-Hodgkin lymphoma. Chronic lymphocytic leukemia (CLL) is the most common leukemia (cancer of blood cells). The purpose of this study is to assess the safety, tolerability, pharmacokinetics, and preliminary efficacy of ABBV-319 in adult participants in relapsed or refractory (R/R) diffuse large b-cell lymphoma (DLBCL), R/R follicular lymphoma (FL), or R/R CLL. Adverse events will be assessed. ABBV-319 is an investigational drug being developed for the treatment of R/R DLBCL, R/R FL, or R/R CLL. This study will include a dose escalation phase to determine the doses of ABBV-319 that will be used in the next phase and a dose expansion phase to determine the change in disease activity in participants with R/R DLBCL, R/R FL, and R/R CLL. Approximately 154 adult participants with R/R B cell lymphomas including R/R DLBCL, R/R FL, and R/R CLL will be enrolled in the study in sites world wide. In the Dose Escalation phase of the study participants will receive escalating intravenously infused doses of ABBV-319 in 21-day cycles, until the Phase 2 dose is determined. In the dose expansion phase of the study participants receive intravenously infused ABBV-319 in 21-day cycles. There may be higher treatment burden for participants in this trial compared to their standard of care. Participants will attend regular visits during the study at an approved institution (hospital or clinic). The effect of the treatment will be frequently checked by medical assessments, blood tests, questionnaires and side effects.
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Number of Dose-Limiting Toxicities (DLT)
Timeframe: Day 42
Number of Participants with Adverse Events (AE)
Timeframe: Up to 30 Months
Maximum Observed Serum Concentration (Cmax) of ABBV-319
Timeframe: Up to 6 Months
Time to Cmax (Tmax) of ABBV-319
Timeframe: Up to 6 Months
Terminal Phase Elimination Half-Life (t1/2) of ABBV-319
Timeframe: Up to 6 Months
Area Under the Serum Concentration Versus Time Curve (AUC) of ABBV-319
Timeframe: Up to 6 Months
Antidrug Antibody (ADA)
Timeframe: Up to 6 Months