UnknownNot Applicable

Oxygen Consumption and Sevoflurane Uptake Based on Physiological Dead Space Estimation

Spain17 participantsStarted 2023-02-01

Plain-language summary

In this study, the investigators will evaluate whether the delivered fraction of oxygen (O2) and sevoflurane administered through a a closed circuit and calculated on the basis of the estimations of O2 consumption (VO2) and sevoflurane uptake (SEVOup) through the inspired-expired fraction gradients of both gases once subtracted the physiological dead space (VDphys), adequately fits the real gases consumption. All participants will be ventilated under a tailored open lung approach (tOLA) strategy.

Who can participate

Age range18 Years – 99 Years

SexALL

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Inclusion Criteria: * Adult subjects (≥ 18 years) scheduled for robotic prostatic surgery at the investigators´ institution * Written informed consent Exclusion Criteria: * Participation in another interventional study * Participants unable to understand the information contained in the informed consent * American Society of Anesthesiologists (ASA) classification grade = IV * Patient in dialysis * Chronic obstructive pulmonary disease (COPD) grade Global Initiative for Chronic Obstructive Lung Disease(GOLD) \> 2 * Functional vital capacity \< 60% or \> 120% of the predicted * Body mass index (BMI) \> 35 kg/m2 * Relation arterial pressure of oxygen (PaO2)/FiO2 \<200 mmHg in the baseline sample * Presence of mechanical ventilation in the 72 hours prior to enrollment * New York Heart Association (NYHA) functional class ≥ 3 * Clinically suspected heart failure * Diagnosis or suspicion of intracranial hypertension * Presence of pneumothorax or giant bullae on preoperative imaging tests * Use of Continuous Positive Airway Pressure (CPAP).

What they're measuring

Change in FeO2 during the closed-circuit ventilation mode

Timeframe: Intraoperative ( From the beginning of the maintenance phase of the anesthesia , with recording every 10 minutes or at any time if a deviation of the end-tidal fraction of O2 higher than 5% of the estimated value is detected)

Change in Fe.sevo during the closed-circuit ventilation mode

Timeframe: Intraoperative (From the beginning of the maintenance phase of the anesthesia , with recording every 10 minutes or at any time if a deviation of the end-tidal fraction of sevoflurane higher than 5% of the estimated value is detected)

Trial details

NCT IDNCT05511584

SponsorFundación Pública Andaluza para la gestión de la Investigación en Sevilla

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2024-03-31

Contact for this trial

Manuel de la Matta, MD

0034 647 49 33 62 mdlmatta@hotmail.com

View on ClinicalTrials.gov More Oxygen Consumption trials