Microneedle Versus Fractional CO₂ Laser for Skin Aging Treatment With Stem Cell Secretome in Indonesian Adult Women

Inclusion Criteria: * Female, aged 35-59 years * Generalized wrinkles on the face * Consent for the 2-month clinical trial (4 times of follow-up with 2 weeks interval) Exclusion Criteria: * Prior history of hypertrophic scars or keloid formation * Prior history of allergy to topical anesthetic and/or retinoic acid cream * Prior history of autoimmune disorders (e.g. systemic lupus erythematosus, rheumatoid arthritis, etc.) * Prior history of malignancies * Prior utilization of skincare products for the past 6 months * Currently under long-term immunosupressants medication (e.g. corticosteroids, biologic agents, cytostatics, etc.) Drop-out Criteria: * Pass away during the clinical trial * Refrain from the clinical trial before the trial completion * Absent for more than two days from the scheduled appointment * Suffer from coronavirus disease 2019 (COVID-19) at any time during the trial * Experience major adverse event(s) caused by topical products or treatments given in the clinical trial (e.g. allergic drug eruption or contact dermatitis). The participants will receive appropriate management if such event occurs.