CompletedNot Applicable

Temporal Window and Episodic Future Thinking in CUD

United States141 participantsStarted 2022-11-30

Plain-language summary

The primary objective is to test the theory of Reinforcer Pathology via manipulation of the temporal window with successive Episodic Future Thinking generation in individuals with cocaine use disorder.

Who can participate

Age range18 Years

SexALL

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Inclusion criteria

✓. demonstrate recent cocaine use and CUD (use in last month, DSM-5 for CUD \> 4)
✓. be 18 years of age or older
✓. have a desire to quit or cut down on their cocaine use, but do not have proximate plans to enroll in treatment for CUD during the study period

Exclusion criteria

✕. meeting moderate to severe DSM-5 criteria for opioid use disorder
✕. having a current diagnosis of any psychotic disorder
✕. having a history of seizure disorders or traumatic brain injury
✕. having any contraindication for participation in the MRI sessions

What they're measuring

Change in Delay Discounting

Timeframe: Over four-weeks of participation (Weekly for four weeks)

Change in Cocaine Demand

Timeframe: Over four weeks of participation (Weekly for four weeks)

Cocaine Craving

Timeframe: Over four weeks of participation (Weekly for four weeks)

Neural activation during fMRI delay discounting task

Timeframe: Over four weeks of participation (Baseline, Week 1, Week 4)

Neural activation during fMRI cocaine purchase task

Timeframe: Over four weeks of participation (Baseline, Week 1, Week 4)

Trial details

NCT IDNCT05507814

SponsorVirginia Polytechnic Institute and State University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-11-24

View on ClinicalTrials.gov More Cocaine Use Disorder trials