WithdrawnPhase 2/3

Enhancing Recovery Through a Combined Mechanobiologic Intervention Following Meniscus Repair

Stopped: Funding not awarded

United States0Started 2025-07

Plain-language summary

Arthroscopic meniscal procedures are the most commonly performed orthopaedic procedure in the U.S. affecting 15% of Americans ages 10-65 years. Meniscus injury is also known to increase the risk of posttraumatic osteoarthritis (PTOA). The current randomized clinical trial will test a novel intervention after meniscal repair that combines an oral senolytic fisetin and real-time biofeedback program to restore joint loading and subsequent return to activity.

Who can participate

Age range18 Years – 45 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

✓. Are male or female, ages 18-45;
✓. Are willing to comply with all study related procedures and assessments;
✓. Are ambulatory as defined by ability to complete functional performance testing;
✓. Medial, lateral or combined meniscus tear treated with surgical repair.
✓. Stable dose of screening/baseline medications for at least 2 months prior to the anticipated date of study drug dosing.

Exclusion criteria

✕. Females who are nursing, pregnant or planning to become pregnant during the duration of study drug dosing;
✕. Males who do not wish to abstain from sex or use contraceptive protection during study drug dosing and for 2 weeks after the last dose;
✕. Subjects who do not have the capacity to consent themselves;
✕. Subjects who are unable to tolerate oral medication;
✕. Subjects having previously undergone any of the following treatments in the stated time window.
✕. Radiographic osteoarthritis (Kellgren-Lawrence Grade 2-4), full thickness chondral defect on MRI, BMI \> 35 kg/m2, concomitant ligament injury, or prior ipsilateral knee ligament or meniscus surgery within prior 12 months of enrollment.
✕. The following intraarticular injections:

What they're measuring

Change in International Knee Documentation Committee (IKDC) Score between baseline and 1 year

Timeframe: Baseline, 1 year

Trial details

NCT IDNCT05505747

SponsorAustin V Stone

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-02

View on ClinicalTrials.gov More Meniscus Tear trials