CompletedPhase 2

Effect of Propofol and Desflurane on Nucleic Acid of Liver Circulating Tumor

China60 participantsStarted 2020-12-01

Plain-language summary

To investigate the effects of perioperative anesthetic drugs propofol and desflurane on circulating tumor nucleic acids (CK7, ELF3, EGFR and EphB4 mRNA) in the blood of patients with liver cancer, so as to provide scientific reference for clinical anesthesia in the perioperative treatment of tumor

Who can participate

Age range18 Years – 75 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age range: 18 to 75 * ASA: I-III * primary liver cancer (CNLC: Stage I-IIIA) * undergoing elective hepatectomy Exclusion Criteria: * Patients with severe bradycardia (HR \< 55bpm) * patients with severe arrhythmias or cardiac dysfunction (EF \< 35%) * patients with severe respiratory lung disease * patients with severe liver and kidney insufficiency epilepsy * patients with severe hyperlipidemia * patients with a history of malignant hyperthermia * patients with propofol or desflurane allergy * patients with history of preoperative chemoradiotherapy * patients who were on immunosuppressive treatment * patients with chronic opioid therapy declined to participate in the study

What they're measuring

The changes of circulating tumor nucleic acids (CK7, ELF3, EGFR and EphB4 mRNA) in peripheral blood of patients with hepatocellular carcinoma after perioperative treatment with propofol and desflurane

Timeframe: Immediately Before induction of anesthesia, Immediately before skinning after induction of anesthesia, during operation, PACU at the end of operation, and on the 7th day after operation

Trial details

NCT IDNCT05502458

SponsorZhejiang Cancer Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2022-08-08

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