Acute myocardial inflammation is an heterogenic syndrome involving different clinical pathologies with different outcome. For the purpose of this study protocol, we focuse on three entities of this syndrome, namely the acute cellular cardiac allograft rejection (ACR), cardiac sarcoidosis (CS) and the immune checkpoint inhibitor induced myocarditis (ICIM), for which non-invasive diagnosis remains challenging. Since accurate diagnosis of myocardial inflammation in an early stage is crucial, this study aims to investigate the accuracy of \[68Ga\]Ga-PentixaFor as a marker of for the presence of inflammatory cells (T-lymphocytes and M1) in described patients. The identification of a correlation between \[68Ga\]Ga-PentixaFor myocardial accumulation with currently accepted diagnostic tools would open up new ways to non-invasively diagnose acute myocardial inflammation.
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Imaging results obtained by [68Ga]Ga-PentixaFor PET/CT - lesion number
Timeframe: 1 year
Imaging results obtained by [68Ga]Ga-PentixaFor PET/CT - lesion site
Timeframe: 1 year
Imaging results obtained by [68Ga]Ga-PentixaFor PET/CT - SUV
Timeframe: 1 year