The investigators will perform two concomitant RCTs, depending on the presence of infected osteosynthesis material at enrolment: \- SALATIO 1. Infected implant not removed (or new material inserted): Randomization 6 vs. 12 weeks (+/- 5 days) of total antibiotic therapy counted since the first debridement for infection. Early switch to oral targeted therapy. \- SALATIO 2. Infected implant without residual material (definitive removal or within the interval of a two-stage exchange): Randomization 3 vs. 6 weeks (+/- 5 days) of total antibiotic therapy counted since the first debridement for infection. Early switch to oral targeted therapy.
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Clinical remission related to the duration of total, postdebridement, antibiotic use
Timeframe: 6 weeks postoperatively, or 1 year postoperatively in case of implant-related orthopedic surgery
Microbiological recurrence in relation to the total, postdebridement, antibiotic use
Timeframe: 6 weeks postoperatively, or 1 year postoperatively in case of implant-related orthopedic surgery