CompletedNot Applicable

Advanced Sperm Selection Techniques and Their Contribution to Blastocyst Euploidy Rates

Egypt515 participantsStarted 2022-08-01

Plain-language summary

Comparing different advanced sperm selection techniques like Physiological ICSI (PICSI) and magnetic activated cell sorting (MACS) in terms of the PGT-A outcomes of each arm blastocysts

Who can participate

Age range18 Years – 50 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Case must have PGT-A for all of her blastocysts * Males diagnosed with abnormal sperm DNA fragmentation index (\> 20%). * Normo responder (\> 5 mature oocytes) * Male will have to refrain from ejaculation no less than 1 day but no greater than 3 days prior semen specimen production on day of ICSI Exclusion Criteria: * Leukocytospermia * Presence of varicocele. * Known genetic abnormality * Use of sperm or oocyte donors * Use of gestational carrier * Presence of any of the endometrial factors that affect embryo implantation such as hydrosalpings, adenomyosis or previous uterine infection * Any contradictions to undergoing in vitro fertilization or gonadotropin stimulation

What they're measuring

Euploidy rate

Timeframe: 15 days post ICSI

Aneuploidy rate

Timeframe: 15 days post ICSI

Low mosaic rate

Timeframe: 15 days post ICSI

High mosaic rate

Timeframe: 15 days post ICSI

Trial details

NCT IDNCT05494216

SponsorGanin Fertility Center

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2024-01-01

View on ClinicalTrials.gov More Sperm DNA Fragmentation trials