TerminatedNot Applicable

The PLATON Network

Stopped: Sponsor Decision

Germany565 participantsStarted 2020-10-28

Plain-language summary

The PLATON Network study is designed to elevate personalized therapy based on genomic tumor profiles in gastrointestinal cancer patients. Hereby, PLATON's study-design focuses on the patient's tumor molecular profiling. Within the network a web application will be developed to link clinical investigators and information on study sites, cancer patients and genetic alteration data, as well as available clinical trials at PLATON's study sites.

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Histologically confirmed diagnosis of hepatocellular carcinoma or intra- cholangiocarcinoma, extrahepatic cholangiocarcinoma or gallbladder carcinoma or pancreatic ductal adenocarcinoma or esophagogastric adenocarcinoma in the advanced setting (adjuvant or neoadjuvant therapy is allowed if completed 6 months prior to enrolment) and no local curative therapy available * Standard first line therapy is planned, or patient is currently receiving first-line therapy * Available tumor-genomic profile ( ≥50-gene panel assay; approved and assessed by central review), unless central tumor genomic profiling is done within a sub-study * ECOG 0-2 * Life expectancy ≥ 6 months Exclusion Criteria: * Not able to understand all implications of study participation * No written informed consent * Age \< 18 years

What they're measuring

Frequency of targetable mutations in gastrointestinal cancer patients

Timeframe: annual interim-analysis (1 year)

Tumor mutations and their impact on treatment decisions in gastrointestinal cancer patients

Timeframe: annual interim-analysis (1 year)

Trial details

NCT IDNCT05489250

SponsorInstitut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2025-06-30