CompletedNot Applicable

Nuclear Magnetic Resonance for Embryo Ploidy Selection

Portugal30 participantsStarted 2021-04-07

Plain-language summary

This study aims to validate the embryo culture medium analysis by nuclear magnetic resonance spectroscopy, as a faster and less-costly alternative to preimplantation genetic test for aneuploidy which could significantly enhance embryo selection and the success rate of assisted reproductive technologies.

Who can participate

Age range

18 Years – 48 Years

Sex

FEMALE

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age: ≥18 and \<49 years old. * Body Mass Index ≥18.5 Kg/m2 and \<30 Kg/m2. * Planned for in vitro fertilization followed by preimplantation genetic test for aneuploidy. * Oocytes retrieval and fertilization by intracytoplasmic sperm injection * Six follicles over 14 mm on the day of the triggering. Gonadotropin-releasing hormone antagonist * Signed and dated informed consent. Exclusion Criteria: * Previous history of poor ovarian response (\<4 oocytes retrieved) with a maximal dose of ovarian stimulation (≥300 IU/day). * Presence of a medical condition which is known to affect assisted reproductive technologies outcome (e.g. thyroid dysfunction). * Active female smoking. * Current use of anti-depressants, anti-psychotics, steroids, antiepileptics or chemotherapy. * Those unable to comprehend the investigational nature of the proposed study.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Comparison of the metabolites present in the culture medium of euploid versus aneuploid embryos.

Timeframe: 6 months

Trial details

NCT IDNCT05488236

SponsorInstituto Valenciano de Infertilidade de Lisboa

Sponsor typeNETWORK

Study typeOBSERVATIONAL

Primary completion2023-06-07

View on ClinicalTrials.gov More Aneuploidy trials